Publications and outputs


Kosgodage US, Matewele P, Mastroianni G, Kraev I, Brotherton D, Awamaria B, Nicholas AP, Lange S and Inal JM. Peptidylarginine Deiminase Inhibitors Reduce Bacterial Membrane Vesicle Release and Sensitize Bacteria to Antibiotic TreatmentFront. Cell. Infect. Microbiol. 9:227. doi: 10.3389/fcimb.2019.00227.

Antwi-Baffour, Samuel, Malibha-Pinchbeck, Memory, Stratton, Dan, Jorfi, Samireh, Lange, Sigrun and Inal, Jameel. Plasma mEV levels in Ghanain malaria patients with low parasitaemia are higher than those of healthy controls, raising the potential for parasite markers in mEVs as diagnostic targets. Journal of Extracellular Vesicles, 9 (1). pp. 1-13. ISSN 2001-3078.


Baraniak I, Kropff B, Ambrose L, McIntosh M, McLean GR, Pichon S, Atkinson C, Milne RSB, Mach  M, Griffiths PD, Reeves MB. Protection from cytomegalovirus viraemia following glycoprotein B vaccination is not dependent on neutralising antibodies. Proc Nati Acad Sci, 2018. 201800224

Baraniak I, Kropff B, Mclean GR, Pichon S, Piras-Douce F, Milne RSB, Smith C, Griffiths PD, Reeves MB. Epitope-Specific Humoral Responses to Human Cytomegalovirus Glycoprotein-B Vaccine with MF59: Anti-AD2 Levels Correlate with Protection from Viremia. The Journal Infectious Diseases, 2018, jiy102



Schrader JW and Mclean GR. Multispecificity of a recombinant annti-ras monoclonal antibody. Journal of Molecular Recognition 31 (2) 2017;e2683

Evans-Osses I, Mojoli A, Monguió-Tortajada M, Marcilla A, Aran V, Amorim M, Inal J, Borràs FE, Ramirez MI. (2017) Microvesicles released from Giardia intestinalis disturb host-pathogen response in vitro. Eur J Cell Biol. Jan 22. doi: 10.1016/j.ejcb.2017.01.005.

Moore C, Kosgodage U, Lange S, Inal JM (2017) The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy. Int J Cancer. 2017 Mar 1. doi: 10.1002/ijc.30672.


Book chapter

Lange, S., Kholia, S., Kosgodage, US, Inal, J.M. (2016) Treatment of prostate cancer using deimination antagonists and microvesicle technology, in Deimination in Human Health and Disease, Volume 2 (Eds Nicholas, Thompson) Springer.


A Manghera and Mclean GR. HCMV vaccination: progress and perspectives of recombinant gB. Future Virology 11(6):439-449, 2016 

Williams GR, Kubajewska I, Glanville N, Johnston SL, Mclean GR. (2016) The potential for a protective vaccine for rhinovirus infections. Expert Rev Vaccines. 15(5): 569-71.



Jorfi S, Ansa-Addo EA, Kholia S, Stratton D, Valley S, Lange S, Inal J (2015) Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo. Sci Rep. 2015 5: 13006. doi: 10.1038/srep13006.

An T, Qin S, Xu Y, Tang Y, Huang Y, Situ B, Inal JM, Zheng L (2015) Exosomes serve as tumour markers for personalized diagnostics owing to their important role in cancer metastasis. Journal of Extracell Vesicles. 19; 4:27522. doi: 10.3402/jev.v4.27522.

Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM, Lange S (2015) A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. Journal of Extracell Vesicles. 2015 4: 26192. doi: 10.3402/jev.v4.26192.

Stratton D, Moore C, Antwi-Baffour S, Lange S, Inal J (2015) Microvesicles released constitutively from prostate cancer cells differ biochemically and functionally to stimulated microvesicles released through sublytic C5b-9. Biochem Biophys Res Commun. 460: 589-95.

Stratton D, Moore C, Zheng L, Lange S, Inal J (2015) Prostate cancer cells stimulated by calcium-mediated activation of protein kinase C undergo a refractory period before re-releasing calcium-bearing microvesicles. Biochem Biophys Res Commun. 460: 511-7.

Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang do W, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS. (2015) EVpedia: a community web portal for extracellular vesicles research Bioinformatics. 31: 933-9.

Hayes, L, INAL, JM, Stratton, D (2015) Re: Inflamed macrophage microvesicles induce insulin resistance in human adipocytes. (Letter to Editor) Nutr. Metab. 12:21

Liu, LW., Virdee, BS, INAL, J, Steer, MB (2015) Microfabrication of conical micro-funnels for drug delivery applications. Micro & Nano Letters 10, 355-357.



Stratton D, Lange S, Kholia S, Jorfi S, Antwi-Baffour S, Inal J (2014) Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. Biochem Biophys Res Commun. 453, 619-24.

Konitsiotis AD, Chang SC, Jovanović B, Ciepla P, Masumoto N, Palmer CP, Tate EW, Couchman JR, Magee AI (2014) Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells. PLoS One. 2014 Mar 7;9(3):e89899.

Ariño J, Aydar E, Drulhe S, Ganser D, Jorrín J, Kahm M, Krause F, Petrezsélyová S, Yenush L, Zimmermannová O, van Heusden GP, Kschischo M, Ludwig J, Palmer C, Ramos J, Sychrová H (2014) Systems biology of monovalent cation homeostasis in yeast: the translucent contribution. Adv Microb Physiol. 64, 1-63.

McLean GR (2014) Developing a vaccine for human rhinoviruses. J Vaccines Immun. 2:16-20.

Privolizzi R, Solari R, Johnston SL, McLean GR (2014) The application of prophylactic antibodies for rhinovirus infections. Antivir Chem Chemother. 23:173-7.



Dinasarapu AR, Chandrasekhar A, Inal J and Subramaniam S (2013) Complement C2. UCSD Molecule Pages, 2, (2) doi:10.6072/H0.MP.A004234.01

Traub S, Nikonova A, Carruthers A, Dunmore R, Vousden K, Gogsadze L, Hao W, Zhu Q, Zhu J, Dymond, M, McLean GR,  Walton RP, Glanville N, Humbles A, Khaitov M, Wells T, Kolbeck R, Leishman AJ, Sleeman MA, Bartlett NW, Johnston SL (2013) An anti-human ICAM-1 antibody inhibits rhinoviral exacerbation of lung inflammation. PLoS Pathogens e1003520.

Glanville N, McLean GR, Guy B, Lecouturier V, Berry C, Girerd Y, Gregoire C, Walton RP, Pearson RM, Kebadze T, Burdin N, Bartlett NW, Almond JW, Johnston SL (2013) Cross-Serotype Immunity Induced by Immunization with a Conserved Rhinovirus Capsid Protein. PLoS Pathogens e1003669.

Privolizzi R, Solari R, Johnston SL, McLean GR (2013) The application of prophylactic antibodies for rhinovirus infections.  Antiviral Chemistry and Chemotherapy in press doi: 10.3851/IMP2578.

Inal JM, Kosgodage U, Azam S, Stratton D, Antwi-Baffour S, Lange S (2013) Blood/plasma secretome and microvesicles. Biochim. Biophys. Acta. 1834, 2317-2325.

Inal JM, Fairbrother U and Heugh S (2013) Microvesiculation and Disease. Biochem. Soc. Trans. 41, 237-240.

Inal JM, Ansa-Addo EA and Lange, S (2013) Interplay of host-pathogen microvesicles and their role in infectious disease. Biochem. Soc. Trans. 41, 258-262.

Inal JM and Jorfi S (2013) The role of microvesicles in cancer progression and drug resistance. Biochem. Soc. Trans. 41, 293-298.

Inal JM and Jorfi S (2013) Coxsackievirus B transmission and possible new roles for extracellular vesicles. Biochem. Soc. Trans. 41, 299-302.

Stratton D, Lange S and Inal JM (2013) Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells. Biochem. Biophys. Res. Commun. 430, 470-475.



Hina K, Simpson R, Inal JM and Mathivanan S (2012) Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation. Plos Biology 10, e1001450.

Thompson RS, Khaskhely NM, Legget DJ, Mosakowski J, Khuder S, McLean G, Westerink MAJ (2012) Isolation and characterization of human polyreactive pneumococcal polysaccharide antibodies. Open Journal of Immunology 2(3):98-110.

Sapparapu G, Planque S, Mitsuda Y, McLean G, Nishiyama Y, Paul S (2012) Constant domain-regulated antibody catalysis. Journal of Biological Chemistry 287:36096-36104.

McLean GR, Walton RP, Shetty S, Paktiawal N, Kebadze T, Gogsadze L, Niespodziana K, Valenta R, Bartlett NW, Johnston SL (2012) Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1. Antiviral Research 95(3):193-201.

Cestari I, Ansa-Addo EA, Deolindo P, Inal JM and Ramirez MI (2012) Trypanosoma cruzi immune evasion mediated by host cell-derived microvesicles. J. Immunol. 188 (4).

Inal JM, Ansa-Addo E, Stratton D, Kholia S, Antwi-Baffour S, Jorfi S and Lange S (2010) Microvesicles in health and disease. Arch. Immunol., Ther. Exp. 60.



Inal JM (2010) Improving Cellular Understanding at CMIRC. PS Public Service Review UK Science and Technology Issue 1, 150-151. 

Inal JM (2011) A new patent for partnership. PS Public Service Review UK Science and Technology Issue 2, 156-157.

Grant R, Ansa-Addo E, Stratton D, Antwi-Baffour S, Jorfi S, Kholia S, Krige L, Lange S, Inal JM (2011) A filtration-based protocol to isolate Plasma Membrane-derived Vesicles and exosomes from blood plasma J. Immunol Methods. 371, 143.



Ansa-Addo E, Lange S, Stratton D, Antwi-Baffour S, Cestari I, Ramirez M, and Inal JM (2010) Human Plasma Membrane-derived Vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukaemia cells. J. Immunol. 185, 5236.

Hind E, Heugh S, Ansa-Addo E, Antwi-Baffour,S and Inal JM (2010) Red Cell PMVs, Plasma Membrane-derived Vesicles calling out for standards. Biochem Biophys. Res. Commun. 398, 278.

Antwi-Baffour S, Kholia S, Aryee YKD, Ansa-Addo EA, Stratton D, Lange S, Inal JM (2010) Human Plasma Membrane-derived Vesicles inhibit the phagocytosis of apoptotic cells – possible role in SLE. Biochem Biophys. Res. Commun. 398, 278.

Scott-Taylor TH, Hourihane JO'B, Strobel S (2010) Correlation of allergen-specific lgG subclass antibodies and T lymphocyte cytokine responses in children with multiple food allergies. Pediatr. Allergy Immunol. 21, 935.

Evans-Osses I, Ansa-Addo E, Inal JM and Ramirez MI (2010) Involvement of lectin pathway activation in the complement killing of Giardia intestinalis. Biochem. Biophys. res. Commun. 395, 382.

Published abstracts and poster/oral presentations

Jorfi S, Ansa-Addo E, and Inal JM (2010) Plasma Membrane-derived Vesicles released from infected HeLa cells by Coxsackie virus B1 induce apoptosis in recipient viable cells. Immunology 131, 85.

Ansa-Addo E, and Inal JM (2010) Trypanosoma cruzi utilisation of host cell membrane repair mechanisms aid invasion. Immunology 131, 84.

Stratton D and Inal JM (2010) Characterisation of cPMVs and sPMVs, constitutive and stimulated Plasma Membrane-derived Vesicles. Immunology 131, 135.

Ansa-Addo E and Inal JM (2010) Host cell release of plasma membrane-derived vesicles, causes damage to the cytoskeleton and leads to activation of Ca²+ -regulated lysosomal repair. Immunology 131, 83.

Cestari IS, Ansa-Addo E, Neto L, Inal JM and Ramirez MI (2010) A novel mechanism to resist complement lysis and invade host: cell triggered by Trypanosoma cruzi (British Society for Parasitology Spring Meeting, Cardiff, 2010).

Ansa-Addo EA, and Inal JM (2010) T. Cruzi Interference With Host Cell Membrane Integrity Triggers The Release Of PMVs: A Mechanism For Entry Into Mammalian Cells J. Immunol. 184, 137.1.

Ansa-Addo EA and Inal JM (2010) Plasma membrane-derived vesicles, promote adhesion and differentiation of THP-1 monocytes in a TGF-ß dependent manner. J. Immunol. 184, 35.15.

Antwi-Baffour S, Kholia S, and Inal JM (2010) aPLA antibodies promote the release of plasma membrane-derived vesicles which inhibit the phagocytosis of apoptotic cells – role in Systemic Lupus Erythematosus J. Immunol. 184, 135.9.

Jorfi S, Ansa-Addo EA, and Inal JM (2010) Plasma membrane-derived Microvesicles (PMVs) released from apoptotic Jurkat cells express upregulated surface Fas and induce apoptosis in recipient viable cells. J. Immunol. 184, 89.45.



de Smith AJ, Purmann C, Walters RG, Ellis RJ, Holder SE, Van Haelst MM, Brady AF, Fairbrother UL, Dattani M, Keogh JM, Henning E, Yeo GS, O'Reilly S. Froguel P, Farooqi IS, Blakemore AI (2009) A deletion of the HBll-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism. Hum. Mol. Genet. 18, 3257.

dos Santos Cestari I, Krarup A, Sim RB, Inal JM and Ramirez MI (2009) Crucial role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi. Mol. Immunol. 47,426.

dos Santos Cestari I, Evans-Osses I, Freitas JC, Inal JM and Ramirez MI (2008)Complement C2 Receptor Inhibitor Trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi. J. Inf. Dis. 198, 1276.

Published abstracts and poster/oral presentations

Ansa-Addo EA, dos Santos Cestari I, Pathak P, Ramirez MI, and Inal JM (2009), Monocytic THP-1 cells stimulated by normal human serum (NHS) release cytokine-bearing plasma membrane-derived vesicles (PMVs), and can be inhibited by methyl-beta-cyclodextrin, calpeptin and Rho-kinase inhibitor, Y-27632. J. Immunol. 182, 98.27.

dos Santos Cestari I, Ansa-Addo E, Inal JM, and Ramirez MI (2008), Trypanosoma cruzi release plasma membrane-derived vesicles (PMVs) to avoid lysis by the complement. Presented at the 24th Annual Meeting of the Brazilian Society of Protozoology/35th Annual Meeting on Chagas disease research 27-29th October, 2008.

dos Santos Cestari, Ansa-Addo E, Pathak P, Ramirez M and Inal JM (2008), The intracellular Trypanosoma cruzi induces the release from monocytesof plasma membrane-derived microvesicles which protect the parasite from host complement. Mol. Immunol. 45:4173.

dos Santos Cestari I, Inal JM and Ramirez MI (2008), Characterization of complement lectin pathway in Trypanosoma cruzi. (British Society of Parasitology meeting, Newcastle).