Cellular Molecular and Immunology Research Centre (CMIRC)

The Cellular Molecular and Immunology Research Centre (CMIRC), founded in 2009 by Prof J Inal, consists of four research themes made up of 14 internal research staff, 12 PhD students and numerous external collaborators from multidisciplinary backgrounds within biomedicine. This community of scientists, together with industrial partners and clinicians, is comprised of several unique groupings with a focus on understanding and harnessing cellular, molecular and immunological properties of biological systems to further research and knowledge in biomedicine.

Aim

Our aim is to use an understanding of cellular and molecular biological processes, immune responses to viruses and cancer cell biogenesis and metastasis, to develop effective interventions for human diseases. A common theme is the characterisation of extracellular vesicles (EVs) in these systems and their use as targeted therapeutic agents. The current research themes therefore are:

  • cancer (novel cancer immunotherapies and sodium, calcium and ion channels in cancer)
  • immunity to viral infections (cytomegalovirus, coxsackievirus and rhinovirus)
  • molecular and cellular medicine (EVs characterisation and application)

Strengths

One of the strengths of CMIRC’s approach is that it is involved directly from the basic laboratory experimentation through to clinical development, aiming to make its research findings translational. It is therefore actively involved, through collaboration with industry and other pan-European laboratories and research centres, in bringing about clinical applications from its findings.

Opportunities

CMIRC is dedicated to collaborating with and training researchers from undergraduate to PhD level and to providing opportunities for postdoctoral researchers. Visiting scientists are always welcome, as are interns that wish to see whether scientific research is for them and to expand their technical repertoire. CMIRC also aims to increase awareness of novel therapeutic approaches to disease and has been a pioneer in extracellular vesicles research and of its potential application; our approach is to make potential future students aware of opportunities in research through seminars, exposure to expert scientists and encouraging participation and discovery. We are also excited that the research conducted has unearthed new scientific information and disease treatment possibilities, many of which have now entered the current teaching and learning curriculum and are provided in modules that form part of the BSc and MSc degree programmes in biosciences within the School of Human Sciences.

 

Peptide structure of the immunologically important part of Schistosoma Tetraspanning Orphan Receptor

Director

Prof Gary McLean

Members

Prof Chris Palmer
Prof Jameel Inal
Dr Eirini Meimaridou
Dr Samireh Jorfi

Useful links

International Society for Extracellular Vesicles
Vesiclepedia database
Journal of Extracellular Vesicles

Student members

Gbemi Adeagbo
Salam Boyeh
Mohammed Abdullahi
Sajida Hashemi
Saima Zaheer
Ogunjobi Adebowale
Saima Siddiqui
Lila Touabi
Feryal Aflatouni
Aliz Arter
Tania Abid

Our research areas

Lead: Dr Gary McLean

Antibodies, vaccine development and extracellular vesicles.

Studies aim to establish correlates of protection for viral diseases, the role of antibodies in viral neutralisation and strategies to design better vaccines.

We are characterising and producing recombinant human antibodies to the AD-2 epitope of human cytomegalovirus (HCMV) and determining the specifics of human IgG and IgA in protective immune responses. These could find utility as biotherapeutics for HCMV infections.

We are developing a novel subunit vaccine for rhinoviruses (RVs) and characterising antibody and T cell responses that are broadly cross-reactive. Recent studies have identified novel antigenic determinants of the rhinovirus capsid and we will produce and further characterise monoclonal antibodies to these epitopes.

Our studies continue in the area of host microvesicles (MVs) and rhinovirus (RV) infection and aim to characterise the kinetics, structure and contents of MVs released from cells following RV infection and to determine their role in virus spread. This is a novel and untested hypothesis for the non-enveloped RV, although previous research has identified a role for MVs in the infection of cells by the related non-enveloped virus coxsackie type B and important human enveloped viruses including hepatitis C virus, human immunodeficiency virus, Epstein-Barr virus and human cytomegalovirus.

The role of intracellular antibody virus neutralisation via the molecule TRIM21. New studies that address a novel mechanism of antibody neutralisation and applicability to RV neutralisation.

Lead: Professor Chris Palmer

Our projects include:

  • Inhibition of microvesiculation to limit drug efflux in prostate cancer. This is coupled to another project on using microvesicles (including those derived from stem cells) as targeted drug delivery vehicles in cancer research.
  • Use of prostate cancer-targeted microvesicles delivering both chemotherapeutic drug and inhibiting subsequent microvesiclation.
  • The role of microvesicles in EMT transdifferentiation in prostate cancer.
  • HPV/EBV and microvesicles in prostate cancer.
  • Microvesicles and complement inhibiting peptides that break tolerance by inhibiting iC3b-CR3 interaction, thus allowing maturation of dendritic cells; Novel immunotherapeutic approaches in prostate cancer therapy.
  • Transdifferentiation and dedifferentiation in monocytic leukaemia.

Lead: Dr Eirini Meimaridou

This theme aims to elucidate the pathogenesis of human diseases at the molecular and cellular level. It explores the biological pathways or technologies that contribute to the prevention, diagnosis and treatment of chronic diseases.

Dr Eirini Meimaridou research interests lie in the endocrine function of the adrenal gland. Dr Meimaridou has previously shown that disturbances in redox homeostasis in the adrenal tissue lead to adrenal insufficient diseases like Familial Glucocorticoid Deficinecy (FGD) [Meimaridou et al, J Endocrinol 2018; Meimaridou et al., Nature 2012].

Redox homeostasis plays an important role in the cellular processes of an organism and is responsible for the balance between reactive oxygen species and antioxidant defense system. Changing the balance of these molecules in the adrenal tissue impacts on the adrenal function leading to adrenal insufficient diseases. Adrenal glands are small endocrine glands located at the top of the kidneys. Despite their small size, the functions they exert are enormous and essential for life. They secrete hormones that control blood sugar, electrolyte balance, and are important for stress response, metabolism and immune suppression. Therefore changes in the structure and function of the adrenal tissue can have detrimental effects on inflammatory, cardiovascular, metabolic syndrome diseases and cancer. Dr Meimaridou’s research aim is to establish the response of the adrenal gland under oxidative stress on inflammation and metabolism.

More about the Cellular Molecular and Immunology Research Centre

Events and seminars at the Cellular and Molecular Immunology Research Centre