Samireh Jorfi

Samireh Jorfi is a senior lecturer in Biosciences with the School of Human Sciences.

An image of Samireh Jorfi

Samireh Jorfi

Samireh is a Biosciences lecturer with the School of Human Sciences at London Met. 

She holds professional memberships with these organisations:

  • American Association of Immunologists (AAI)
  • British Society for Immunology (BSI)
  • International Society for Extracellular Vesicles (ISEV)
  • Royal Society of Biology (MRSB)

Qualifications

  • MA: Learning and Teaching in Higher Education, London Metropolitan University (2016-2018)
  • PhD: London Metropolitan University, CMIR, ‘Thesis: The Role of Microvesicles in Cancer and Viral Infection’(2009-2012)
  • BSc Honours (1st class), Biomedical  Science, London Metropolitan University (2007-2009).
  • Jorfi S, Ansa-Addo EA, Kholia S, Stratton D, Valley S, Lange S, Inal J. (2015) Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo Sci Rep. 2015 Aug 25;5:13006. doi: 10.1038/srep13006.
  • Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM, Lange S.(2015) A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. J Extracell Vesicles. 2015 Jun 19;4:26192. doi: 10.3402/jev.v4.26192. eCollection 2015.
  • Stratton, D, Lange,S,  Kholia, S, Jorfi,S, and Inal, JM (2014). Label-free real-time acoustic sensing of microvesicle release from prostate cancer (PC3) cells using a Quartz Crystal Microbalance. Biochem Biophys Res Commu.  pii: S0006-291X(14)01775-6. doi: 10.1016/j.bbrc.2014.09.132.
  • Jorfi, S, Ansa-Addo, EA ,  Kholia, S, Stratton,D, Lange,S,  and Inal, JM (2014). Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in a xenograft mouse model of prostate cancer. (Under revesion))
  • Jorfi, S, Ansa-Addo, EA and Inal, JM (2014). CVB1-induction of apoptotic MVs reveals a nonlytic MV-to-cell mechanism of virus transmission to new cells. (Submitted). 
  • Jorfi,S, and Inal, JM (2013). Coxsackievirus B transmission and possible new roles for extracellular vesicles. Biochem Soc Trans. 1;41(1):299-302. doi: 10.1042/BST20120272.
  • Jorfi,S, and Inal, JM (2013). The role of microvesicles in cancer progression and drug resistance, Biochem Soc Trans. 1;41(1):293-8. doi: 10.1042/BST20120273.
  • Stratton,D, Lange, S,  Williams, G, Jorfi, S, Antwi-Baffour, S,  Kosgodage, U and  Inal, JM (2013). Microvesicles released constitutively and upon stimulation retain parental features but exhibit distinct properties. (Under revision)
  • Grant, R, Ansa-Addo, E, Stratton, D, Antwi-Baffour, S, Jorfi, S, Kholia, S, Krige, L, Lange, S, INAL, JM. (2011) A filtration-based protocol to isolate Plasma Membrane-derived Vesicles and exosomes from blood plasma J. Immunol Methods. 371,143.
  • Inal, JM, Ansa-Addo, E, Stratton, D, Kholia, S, Antwi-Baffour, S, Jorfi, S and Lange, S (2010) Microvesicles in health and disease. Arch. Immunol., Ther. Exp. 60.

Published abstracts

  • Jorfi, S, and Inal, JM (2012) Cancer cell expulsion of anticancer drugs through shedding of microvesicles: Association with drug resistance and tumour survival. Biochemical Society Transactions.
  • Jorfi, S, Ansa-Addo, EA and Inal, JM (2012) Coxsackie virus entry and spread in HeLa cells is aided by microvesicle release. J Immunol 188:170.22
  • Jorfi, S, Ansa-Addo, EA and Inal, JM (2010). Plasma Membrane-derived Vesicles derived from apoptotic Jurkat cell express upregulated surface Fas and induce apoptosis in recipient viable cells. J Immunol 184.
  • Jorfi, S, Ansa-Addo, E, and Inal, JM (2010) Plasma Membrane-derived Vesicles released from infected HeLa cells by Coxsackie virus B1 induce apoptosis in recipient viable cells J Immunol   184:8945

 

Email: s.jorfi@londonmet.ac.uk