A series of lectures will be held at London Met in conjunction with the Physiological Society.
Date: 03 May 2023
The GL Brown Lecture Series is one of several prestigious lectures from The Physiological Society (PhySoc). The lecture focuses on early career audiences to stimulate an interest in physiology. Each year, the Society announces the awardee, following which, departments around the country can invite the GL Brown Lecturer to their institutions to highlight their research.
The Physiological Society 2022 GL Brown Prize Lecture Awardee is Professor Sandip Patel FRSB MAE is a Professor at University College London (UCL). Professor Lijun Shang at School of Human Sciences was chosen to host one of his GL Brown Prize Lecture in London Metropolitan University. This is the second time that London Metropolitan University to host this kind of prestigious PhySoc lectures.
The lecture will be hybrid. This lecture will be taking place on campus at TM3-03 and online at 12:00 on 10 May. The title for this talk is ‘Ca2+ Signalling Through Acidic Organelles: From Ringer to the Cell’s Inner.’
Lijun outlined the focus of his lecture. “Changes in intracellular Ca2+ underpin our physiology. These changes are usually ascribed to entry of Ca2+ from the outside of the cell or release from the endoplasmic reticulum. But it is now clear that the so called ‘acidic Ca2+ stores’ are also part of the Ca2+ network.”
“In this lecture, I discuss how lysosomes, once viewed solely as the cell’s recycling centre, are in fact dynamic Ca2+ signalling organelles in intimate contact with endoplasmic reticulum Ca2+ stores. I focus on a family of endo-lysosomal ion channels – the two-pore channels – that are activated by the second messenger NAADP and describe some of their recently discovered properties which challenge the textbook view of how ion channels work. “
Professor Sandip Patel trained as a medical biochemist (Birmingham) and obtained his PhD in pharmacology (Cambridge) with Colin Taylor followed by postdoctoral work with Andrew Thomas (Philadelphia/Newark) and Antony Galione (Oxford) as a Wellcome Trust International Travel Prize fellow. He started his own lab in Oxford which he moved to London in 2001, where is currently the Deputy Head of the Department of Cell and Developmental Biology. Sandip’s work has helped develop the concept that acidic organelles such as lysosomes serve as patho-physiologically relevant stores of Ca2+. He is and a member of several editorial boards (including Cell Calcium) and funding agency panels, including the Medical Research Council.
Following the lecture there will be an opportunity to respond to any audience questions.
This seminar is open to all students and staff at London Metropolitan University. Book your free place on Eventbrite.