Infectious disease research theme
Our studies in the area of host microvesicles and rhinovirus infection include:
- Characterising the kinetics, structure and contents of microvesicles released from cells following rhinovirus (RV) infection;
- Inhibiting microvesicle release and adding exogenous microvesicles to modulate RV infections in vitro;
- Determining microvesicles in nasal and bronchoalveolar lavage samples obtained following experimental RV infections.
This is a novel and untested hypothesis for the non-enveloped RV, although previous research has identified a role for MV’s in the infection of cells by the related non-enveloped virus coxsackie type B and important human enveloped viruses including hepatitis C virus, human immunodeficiency virus, Epstein-Barr virus and human cytomegalovirus.