Infectious disease research theme

Dr Gary McLean (Reader, Deputy Director)
Sarah Azam MSc (PhD student)
Professor Jameel Inal 
Dr Samireh Jorfi  (Lecturer)     
Simona Velkova (Research assistant)

Our studies in the area of host microvesicles and rhinovirus infection include:

  1. Characterising the kinetics, structure and contents of microvesicles released from cells following rhinovirus (RV) infection;
  2. Inhibiting microvesicle release and adding exogenous microvesicles to modulate RV infections in vitro;
  3. Determining microvesicles in nasal and bronchoalveolar lavage samples obtained following experimental RV infections.

This is a novel and untested hypothesis for the non-enveloped RV, although previous research has identified a role for MV’s in the infection of cells by the related non-enveloped virus coxsackie type B and important human enveloped viruses including hepatitis C virus, human immunodeficiency virus, Epstein-Barr virus and human cytomegalovirus.