Professor Kebreab Ghebremeskel

Research interests

  • Membrane lipids and cell function
  • In-utero nutritional environment and pre and post-natal development and health
  • Nutrients and gene interaction
  • Comparative biochemistry and nutritional ecologyerests

Current research

  • Membrane lipid abnormality in gestational diabetes
  • Essential fatty acid supplementation in diabetic pregnancy and prevention of the genesis of diabetic risk factors in their foetus
  • Alternative dietary therapy for the prevention of stroke in children with sickle cell disease
  • Therapeutic benefits of omega-3 and omega-6 polyunsaturated fatty acids and gamma tocopherol for patients with the remitting and relapsing form of Multiple Sclerosis
  • Dietary docosahexaenoic acid and cognitive function in Omani school children
  • Docosahexaenoic acid supplementation to improve pregnancy outcome in population with low omega-3 fat intake
  • Docosahexaenoic acid supplementation to prevent seizure in patients with refractory epilepsy

Funding 

Funding BodyAmountDurationStudy
Phylax £30,000 2014 Nutrition in pregnancy complicated with diabetes
Vifor International £35,000 2013 Delta-6 & 5 desaturase activities in diabetic pregnancy
Ministry of Agriculture and Fisheries Wealth, Sultanate of Oman £192,830 2012-2014 The impact of fish and fish oil capsule intake on omega-3 fatty acid status, health and cognitive function of Omani school children of 9-10 years old living in Muscat.
Vifor International £31,000 2010-2012 Omega-3 fatty acid supplementation of Polish children with Asperger syndrome
Efamol/Wessen International £15,000 2010-2012 Omega-3 fatty acids for prevention of stroke in sickle cell patients
Vifor Pharma £55,883 2010-2013 Omega-3 fatty acids supplementation of Polish children with attention deficit hyperactivity disorder
The Mother and Child Foundation £269,000 2007-2012 Diabetic pregnancy and fatty acid insufficiency: Implications for neuro-visual development of offspring
Equazen Ltd £150,000 2008-2011 Omega-3 fatty acids supplementation trial in women with gestational diabetes
EU FP6 Marie Curie Action - Transfer of Knowledge €1,285,600 2006-2010 Lipidomics in Human Developement, Health & Chronic disease

 

Publications (since 2008)

 

  • Daak AA, Elsamani E, Ali EH, Mohamed FA, Abdel-Rahman ME, Elderdery AY, Talbot O, Kraft P, Ghebremeskel K, Elbashir MI, Fawzi W (2016) Sickle cell disease in western Sudan: genetic epidemiology and predictors of knowledge attitude and practices. Trop Med Int Health. 21(5): 642-653.
  • Min Y, Djahanbackhch O, Hutchinson J, Eram S, Bhullar AS, Namugere I, Ghebremeskel K (2016) Efficacy of docosahexaenoic acid-enriched formula to enhance maternal and fetal blood docosahexaenoic acid levels: randomized double-blinded placebo controlled trial of pregnant women with gestational diabetes mellitus. Clin Nutr 35(3): 608-614.
  • Al-Ghannami AA, Sedlak E, Hussein IS, Min Y, Al-Shmmkhi SM, Al-Oufi HS, Al-Mazroui A, Ghebremeskel K (2016) Lipid-soluble nutrient status of healthy Omani school children before and after intervention with oily fish meal or re-esterified triglyceride fish oil. Nutrition 32(1):73-78.
  • Daak AA and Ghebremeskel K (2015) Blood Cell Membrane Omega-3 (n-3) Fatty Acid Abnormality and Supplementation in Patients with Sickle Cell Anaemia. In Handbook of Lipids in Human Function: Fatty Acids. Eds. Ronald Ross Watson, Fabien De Meester, Chapter 72, PP. 711-730.
  • Matsudaira T, Gow RV, Kelly J, Murphy C, Potts L, Sumich A, Ghebremeskel K, Crawford MA, Taylor E (2015) Biochemical and Psychological Effects of Omega-3/6 Supplements in Male Adolescents with attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Clinical Trial. J Child Adolesc Psychopharmacol. 25(10):775-782. 
  • Madu AJ, Abuknesha N, Ghebremeskel K (2015) The role of lipids in inflammation: Review of the evolving pathogenesis of sickle cell disease (Review). Biol Med (Aligarh) 7;4: 1000244
  • Dornellas AP, Watanabe RL, Pimentel GD, Boldarine VT, Nascimento CM, Oyama LM, Ghebremeskel K, Wang Y, Bueno AA, Ribeiro EB (2015) Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions. Prostaglandins Leukot Essent Fatty Acids. 102-103:21-29
  • Daak A, Elderdery AY, Elbashir LM, Mariniello K, Mills J, Scarlett G, Elbashir MI, Ghbremeskel K (2015) Omega 3 (n-3) fatty acids down-regulate nuclear factor-kappa B (NF-kB) genen and blood cell adhesion molecule expression in patients with homozygous sickle cell disease. Blood Cells Mol Dis 55(1):45-55
  • Min Y, Djahanbakhch O, Hutchinson J, Bhullar AS, Raveendran M, Hallot A, Eram S, Namugere I, Nateghian S, Ghebremeskel K (2014) Effect of docosahexaenoic acid-enriched fish oil supplementation in pregnant women with Type 2 diabetes on membrane fatty acids and fetal body composition-double-blinded randomized placebo-controlled trial. Diabet Med. 31(11): 1331-1340
  • Min Y, Blois A, Geppert J, Khalil F, Ghebremeskel K, Holmsen H (2014) Dietary fat intake, circulating and membrane fatty acids composition of healthy Norwegian men and women. J Hum Diet Nutr 27(1): 69-75
  • Crawford MA, Broadhurst CL, Cunnane S, Marsh DE, Schmidt WF, Brand A, Ghebremeskel K (2014) Nutritional armour in evolution: docosaehxaenoic acid as a determinant of neural, evolution and hominid brain development. Mil Med 179(11 Suppl): 61-75.
  • Daak AA, Ghebremeskel K (2013) Omega-3 fatty acids and sickle cell disease: Intriguing association and promising therapeutic effect. Lipid Technology 25(12): 275-277
  • Daak A, Ghebremeskel K, Mariniello K, Hassan Z, Attallah B, Clough P, Elbashir MI (2013) Oxidative stress and intravascular haemolysis in homozygous sickle cell patients supplemented with omega 3 fatty acids. Prostaglandins Leukot Essent Fatty acids 89(5):305-311
  • Nyuar KB, Min Y, Mohammed MDA, Abukashawa  SMA, Daak AA, Ghebremeskel K (2013) Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. Prostaglandins Leukot Essent Fatty Acids 89(2-3):65-69
  • Gow RY, Vallee-Tourangeau F, Sumich A, Crawford M, Ghebremeskel K, Bueno A, Hibbeln JR, Taylor E and Rubia K (2013) Omega-3 fatty acids are related to abnormal emotion processing in adolescent  boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 88(6): 419-429
  • Gow RV, Vallee-Tourangeau F, Crawford M, Amador-Bueno A, Ghebremeskel K, Hibbeln JH, Taylor E and Rubia K (2013) Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 88(6): 411-418
  • Sumich AL, Matsudaira T, Gow R, Ibrahimovic A, Ghebremeskel K, Crawford M and Taylor E (2013) Fatty acid correlates of temperament in adolescent boys with attention deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids [88(6):431-436
  • Daak AA, Ghebremeskel K, Hassan Z, Attallah B, Azan HH, Elbashir MI (2012) Effect of omega-3 fatty acid supplementation in patients with sickle cell anaemia: randomized, double-blind, placebo-controlled trial. Am J Clini Nutr 97(1): 37-44 
  • Neville MM, Geppert J, Min Y, Grimble G, Crawford MA, Ghebremeskel K (2012) Dietary fat intake, body composition and blood lipids of university men and women. Nutr Health 21(3):173-185.
  • Crawford M, Leigh Broadhurst C, Guest M, Naqar A, Wang Y, Ghebremeskel K, Scmidt WF (2012) A Quantoun theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. 2012 88(1): 5-13
  • Nyuar KB, Ghebremeskel K, Crawford MA. Sudanese women's and neonates' vitamin A status. Nutr Health. 2012 Jan;21(1):45-55.
  • Hussein IS, Min Y, Ghebremeskel K, Gaffar AM (2012) Iodine status and fish intake of Sudanese school children living in Red Sea and White Nile region. Public Health Nutr 4:1-7.
  • Bueno AA, Ghebremeskel K, Bakheit KH, Elbashir MI, Adam I (2011) Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese preeclamptic subjects whose backgrounds diet is high in carbohydrate. J Obst Gynaecol 32(3):241-6.
  • Daak A, Ghebremeskel K, Elbashir MI, Bakhita A, Hassan Z (2011) Hydroxyurea therapy mobilises arachidonic acid from inner cell membrane aminophospholipids in patients with homozygous sickle cell disease. J Lipids 2011: 718014
  • Min Y, Ghebremeskel K, Geppert J, Khalil F (2010) Effect of storage temperature and length on fatty acid composition of fingertip blood collected on filter paper. Prostaglandin Leukot Essent Fatty Acids 84(1-2): 13-18
  • Al-Sinani M, Min Y, Ghebremeskel K, Qazaq HS (2010) Effectiveness of and adherence to dietary and lifestyle counselling on metabolic control in type 2 diabetic Omani patients. Sultan Qaboos Uni Med J 10(3): 61-69
  • Nyuar KB, Min Y, Ghebremeskel K, Khalil AKH, Elbashir MI, Crawford MA (2010) Milk of northern Sudanese mothers whose traditional diet is high in carbohydrate contains low docosahexaenoic acid. Acta Paediatrica 99(12): 1824-1287
  • Bakheit KH, Ghebremeskel K, Pol K, Elbashir MI, Adam I (2010) Erythrocyte omega-3 and omega-6 fatty acids profile in Sudanese women with pre-eclampsia. J Obstet Gynaecol 30(2):151-154
  • Bakheit KH, Ghebremeskel K, Zaiger G, Elbashir MI, Adam I (2010) Erythrocyte antioxidant enzymes and plasma antioxidant vitamins in Sudanese women with pre-eclampsia. J Obstet Gynaecol 30(2):147-150
  • Brand A, Bauer NG, Hallott A, Goldbaum O, Ghebremeskel K, Reifen R, Richter-Landsberg C (2010) Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes upregulation of heme oxygenase-1 (HSP32). J Neurochem. 113(2):465-476.
  • Geppert J, Min Y, Neville M, Lowy C, Ghebremeskel K (2009) Gender specific fatty acid profiles in platelet phosphatidyl-choline and -ethanolamine. Prost Leukot Essent Fatty Acids 82(1):51-56
  • Wang Y, Lehane C, Ghebremeskel K, Crawford MA (2009) Modern organic and broiler chickens sold for human consumption provide more energy from fat than protein. Public Health Nutr. 4:1-9.
  • Sumich AL, Matsudaira T, Gow R, Ibrahimovic A, Ghebremeskel K, Crawford MA, Taylor E (2009) Resting state electroencephalographic correlates with red cell long chain fatty acids, memory performance and age in adolescent boys with attention and hyperactivity disorder. Neuropharmacology 57(7-8):708-14
  • Zhang J, Wang Y, Meng L, Wang C, Zhao W, Chen J, Ghebremeskel K, Crawford MA (2009) Maternal and neonatal plasma n-3 and n-6 fatty acids of pregnant women and neonates from three regions of China with contrasting dietary patterns. Asia Pacific J Clin Nutr 18(3):377-88.
  • Caraveo-Patin J, Wang Y, Soto LA, Ghebremeskel K, Lehane C, Crawford MA (2009) Eco-physiological repercussions of dietary arachidonic acid in cell membranes of active tissues of the Gray whale.  Marine Ecology 30(4):437-447
  • Izzeldin SH, Crawford MA, Ghebremeskel K (2009) Salt fortification with iodine: Sudan situation analysis. Nutr Health 20(1): 21-30.
  • Gow RV, Matsudaira T, Taylor E, Rubia K, Crawford M, Ghebremeskel K, Ibrahimovic A, Vallée-Tourangeau F, Williams LM, Sumich A (2009) Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids. 80(2-3): 151-156
  • Meng LP, Zhang J, Wang YQ, Wang CR, Ghebremeskel K, Zhao WH (2008) Dietary fatty acids intake and their food sources in pregnant women from different aquatic-product intake regions in China. Acta Nutrimenta Sinica, 30(3): 249-252.
  • Ren H, Ghebremeskel K, Okpala I, Ugochukwu CC, Crawford A, Ibegbulam O (2008) Patients with sickle cell disease have reduced blood antioxidant protection. Int J Vit Nutr Res 78(3):139-147.
  • Clauss M, Diernfeld ES, Bigley KE, Wang Y, Ghebremeskel K, Hatt JM, Flach EJ, Behlert O, Castell JC, Streich WJ, Bauer JE (2008) Fatty acid status in captive and free-ranging black rhinoceroses (Diceros bicornis). J Animal Physiol Animal Nutr 92(3):231-241.

Book chapters

  • Crawford MA, Wang Y, Lehane C and Ghebremeskel K (2010) Chapter 6. Fatty acid ratios in free living and domestic animals. In: Modern Dietary Fat Intakes in Disease Promotion, Ed. Watson, RR.; De Meester, F.; De Meester, F.; Zibadi, S. Humana Press, Springer, New York, Dordrecht, Heidelberg, London, p95-108.
  • Crawford M, Broadhurst CL, Galli C, Ghebremeskel K, Holmsen H, Saugstad LF, Schmidt WF, Sinclair AJ, Cunnane SC (2008) The role of docosahexaenioc and arachidonic acids as determinants of evolution and hominid brain development. Fisheries for Global Welfare and Environment, Proceeding of 5th World Fisheries Congress, LNRC - docosahexaenioc and arachidonic acids.
  • Zhou D, Ghebremeskel K, Crawford MA, Reifen R (2007) Chapter 11. The effect of vitamin A deficiency and inflammation on long chain polyunsaturated fatty acids in rat colon and liver membranes. In: Malnutrition Research Advances, Editor Vesler L.W., Nova Science Publishers, Inc, p183-212.
  • Ghebremeskel K, Min Y, Thomas B, Crawford M (2006) Chapter 91. The role of essential fatty acids and antioxidants in neurovascular development and complications of prematurity. pp993-1000, In: Text book of Perinatal Medicine. Ed. Kurjak A, Parthenon Publishing
  • Ghebremeskel K, Thomas B, Min Y, Stacey F, Koukkou E, Lowy C, Erskine K, Crawford MA and Offley-Shore B (1999) Fatty acids in pregnant diabetic women and neonates: implications for growth and development. In: Essential Fatty Acids and Eicosanoids, (Eds. Riemersma R, Armstrong R, Kelly R and Wilson R), Chapter 23:104-107.
  • Ghebremeskel K, Crawford MA (1998) The role of essential fatty acids and antioxidants in neurovascular development and complications of prematurity. In: Textbook of Perinatal Medicine. Kurjak A Ed. Parthenon Publishing, Vol.1, p853-859.
  • Crawford M, Ghebremeskel K (1996) The equation between food production, nutrition and health. In: Food Ethics, Mepham B Ed., Routledge, London, p64-83.
  • Crawford M, Doyle W, Drury P, Ghebremeskel K, Harbige L, Leyton J, Williams G (1989) The food chain of n-6 and n-3 fatty acids with special reference to animal products. In: Dietary w3 and w6 Fatty Acids – Biological Effects and Nutritional Essentiality. Galli C and Simopoulos AP Eds., Plenum press, New York, p5-19.

 

View previous publications.


PhD, CBiol FSB, Director of LNRC

k.ghebremeskel@londonmet.ac.uk