London Metropolitan University Research Institutes
 

Dr Nick Wardle



Projects

  • Syntheses of MRI Contrast agents - focusing on 1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DO3A) and derivatives as metal chelators
  • Investigation of novel routes to achieve selective protease enzyme inhibition

 

Publications

  • Hudson HR, Wardle N, Bligh SWA, Greiner I, Grün A, Keglevich G (2012) N-Heterocyclic Dronic Acids: Applications and Synthesis, Minireviews Med. Chem., 12:313-325.
  • Yang YC, Crowder J, Wardle NJ, Yang L, White KN, Wang ZT, Bligh SWA (2011) 1H-NMR study of monocrotaline and its metabolites in human blood, Food and Chemical Toxicology,49:2793-2799.
  • Wardle NJ, Kalber T, Bell JD, Bligh SWA (2011) Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features, Bioorg. Med. Chem. Letters, 21:3346-3348.
  • Wardle NJ, Hudson HR, Bligh SWA (2010) O-Phosphotyrosine analogues; synthesis and therapeutic role in modulation of signal transduction, Current Organic Chemistry, 14:426-446.
  • Wardle NJ, Hudson HR, Matthews RW, Nunn C, Vella C and Bligh SWA (2009) Presentation of the ²-Carboxamidophosphonate Arrangement in Substrate Structures Targeting HIV-1 PR. Letters in Drug Design & Discovery 6:139-145.
  • Wardle NJ, Bligh SWA and Hudson HR (2008) Organophosphorus Compounds: Intervention in Mechanisms of Signal Transduction Relevant to Proliferative, Immunological and Circulatory Disorders Curr. Med. Chem. 15: 2230-2257.
  • Wardle NJ, Bligh SWA and Hudson HR (2007) Omega-Phosphinyl-alpha-amino acids: synthesis and development towards use as therapeutic agents, Current Organic Chemistry, 11: (18) 1635-1651.
  • Wardle NJ, Herlihy A, So PW, Bell JD and Bligh SWA (2007) Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[²,D-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,
    10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex. Bioorganic and Med. Chem. 15:4714-4721.
  • Wardle NJ, Bligh SWA and Hudson HR (2005) Organophosphorus chemistry: Therapeutic intervention in mechanisms of viral and cellular replication, Current Organic Chemistry, 9: 1803-1828.
  • Bashall A, Bligh SWA, Garrud C, Padhye S, McPartlin M, Wardle N and White KN (2003) Reaction of (C-(6-aminomethyl-pyridin-2-yl)-methylamine)chloro-platinum(II) with nucleosides and its biological activity. J. Chem. Soc. Dalton Trans., 184-188.
  • Wardle NJ (1998) "Syntheses and Characterisation of 1-Acetamido-2,2-biscarbamoyl-ethanephosphonate derivatives" PhD Thesis, University of North London

 

Grants and Funding

  • Research Fellowship - Imperial College of Science, Technology and Medicine, Department of Cancer Medicine (RA1A Scale) 2002-2003





 

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