Professor Li-Min Zhu

Professor of Chemical Biology and Drug Delivery
Distinguished Professor of Donghua University
Head, Group for Enzyme Chemistry and Drug Delivery Materials, Institute of Biological Sciences & Biotechnology, Donghua University, Shanghai, China
Joint Head, UK-China Joint Laboratory for Therapeutic Textiles (UCLTT)

Research Interests

Biocatalysis & enzyme chemistry
Design, modification, synthesis and applications of new enzymes
Research on enzyme catalytic reactions and mechanism
Pharmaceutical biotechnology
Enzymes in new drug's synthesis with nucleoside or other structures
Research and development of textile delivery systems and drug delivery materials
Research and development of therapeutic textiles
Resaerch and development of intelligent and functional textile products

Professional Activities

Academic Member, OSSO State Key Lab, Chinese Academy of Sciences

Visiting Professor, Zhejiang University
Guest Professor, Shanghai University of Traditional Chinese Medicine
Vice-Chairman of Council, Journal of Pharmaceutical Biotechnology, Chinese Pharmaceutical Association.
Senior Member of Editorial Board, Journal of Chinese Medical Drugs, Chinese Pharmaceutical Association.

Publications

Fu S.-J., Zhu L-M., Stereoselective Enzymatic Synthesis of b-D-2'',3''-didehydro-2'',3''-dideoxy- 5-fluorocytidine, Tetrahedron Lett., in press.
Fan H.-W., Zhu L.-M., Enzymatic Synthesis of New Antiarrhythmic Drug: CVT-510, Biocatalysis and Biotransformation, in press.
Wang H.-P., Zhu L-M., Enzymatic Synthesis of Leukotriene Biosynthesis Inhibitor BAY-X-1005, Tetrahedron Lett., in press.
Fu S.-J., Zhu L-M., Enzymatic Synthesis of b-D-2'', 3''-unsaturated-5-fluorocytidine from b-D-2'',3''- unsaturated thymidine, Biocatalysis and Biotransformation, in press.
Fu S.-J., Zhu L-M., (2005). A new Dual Antiretroviral Drug Against HIV and HBV: L-D4FC, Chinese J. New Drugs, 14(9), 1201-1205.
Xin J.-Y., Cui J.-R., Niu J.-Z., Hua S.-f., Xia C.-G., Li S.-B., Zhu L.-M. (2004). Biosynthesis of Methanol from CO2 and CH4 by Methanotrophic Bacteria, Biotechnology. 3(1), 67-71.
Carrey E.A., Smolenski R.T., Edbury S.M., Laurence A., Marinaki A.M., Duley J.A., Zhu L.-M., Goldsmith D.A., Simmonds H.A., (2004).An Unusual Pyridine Nucleotide Accumulating in Erythrocytes: Its Identity and Positive Correlation with Degree of Renal Failure, Nucleoside, Nucleotides & Nucleic Acids, 23, 1135-1139.
Xin J.-Y., Cui J.-R., Niu J.-Z., Hua S.-f., Xia C.-G., Li S.-B., Zhu L.-M. (2004). Production of Methanol from Methane by Methanotrophic Bacteria", Biocatalysis & Biotrasformation, 22(3), 225-229.
Carrey E.A., Smolenski R.T., Edbury S.M., Laurence A., Marinaki A.M., Duley J.A., Zhu L.-M., Goldsmith D.A., Simmonds H.A, (2003). Origin and Characteristics of Pyridine Nucleotide Accumulating in Erythrocytes: Positive Correlation with Degree of Renal Failure, Clin. Chim. Acta, 335, 117-129.
Xin J.-Y., Cui J.-R., Niu J.-Z., Chen J.-B., Li S.-B., Xia C.-G., Zhu L.-M. (2003). Continuous Biocatalytic Synthesis of Epoxypropane using Biofilm Reactor, Process Biochem., 38, 1739-1746.
Xin J.-Y., Cui J.-R., Niu J.-Z., Chen J.-B., Li S.-B., Xia C.-G., Zhu L.-M. (2002). Epoxypropane Biosynthesis by Methylomonas sp. GYJ3: Batch and Continuous Studies, World J. Microbio & Biotech., 18, 609-614.
Xin J.-Y., Cui J.-R., Hu X.-X., Li S.-B., Xia C.-G., Zhu L.-M., (2002). Particulate Methane Monooxygenase from Methylosinus Trichosporium is a Copper-containing Enzyme, Biochem. & Biophys. Res. Comm., 295(1), 182-186.
Xin J.-Y., Cui J.-R., Hu X.-X., Li S.-B., Xia C.-G., Zhu L.-M., (2002). Fine Separation and Characterization of Candida rugosa Lipase Isoenzymes, J. Basic Microbio., 42(5), 355-363.
Wang L.-L., Hu X.-X., Xin J.-Y., Cui J.-R., Li S.-B., Zhu L.-M., (2001). HPLC Separation of the Reaction Mixture in Mammalian Cell Catalyzed by the Multienzyme, Acta Chimica Sinica, 59(5), 788-792.

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