London Metropolitan University Research Institutes
 

Professor Annie Bligh



Projects

  • Structure elucidation of herbal compounds
  • Screening of small molecules in drug discovery
  • Design and synthesis of lanthanide complexes as MRI contrast agents
  • Organophosphorus compounds and their metal complexes in agriculture and biology
  • Macrocyclic compounds and their biomedical applications

 

Publications

  • Ogegbo OL, Dissanyake W, Crowder J, Asekun O,  Familoni O, Branford-White CJ, Bligh SWA (2012) Urinary 1H-NMR Metabonomics Study on Intervention Effects of Soya Milk in Africans, Phytother. Res., 26:127-135.
  • Cooke BR, Bligh SWA, Cybulski ZR, Gibson GG, Ioannides C, Hall M (2012) Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes, Drug Metab. Dispos., 40:70-75.
  • Machakanur SS, Patil BR, Badiger DS, Bakale RP, Gudasi KB, Bligh SWA (2012) Synthesis of novel tri-arm star shaped 1,3,5-triazine hydrazones from 2,4,6-tris(4-acetylphenoxy)-1,3,5-triazine core, Lett Org. Chem., 9:29-34.
  • Han H, Yang L, Xu Y, Bligh SWA and Wang Z-T (2011) Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry, Rapid Commun. Mass Spectrom., 25:3339-3350.
  • Yu D-G, Branford-White C, Bligh SWA, White K, Chatterton NP, and Zhu L-M. (2011) Self-assembled liposomes from amphiphilic electrospun nanofibers, Soft Matters, 7:8239-8247. 
  • Patil BR, Machakanur SS, Hunoor RS, Badiger DS, Gudasi KB, Bligh SWA (2011) Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives, Der Pharma Chemica, 3:377-388.
  • Yang YC, Crowder J, Wardle NJ, Yang L, White KN, Wang ZT, Bligh SWA (2011) 1H-NMR study of monocrotaline and its metabolites in human blood, Food and Chemical Toxicology,49:2793-2799.
  • Patil BR, Machakanur SS, Badiger DS, Hunoor RS, Gudasi KB, Nethaji M, Bligh SWA (2011) Hexa-arm star shaped hydrazone derivatives from hexakis(4-formylphenoxy)-cyclotriphosphazene core, J. Mol. Struct. 1003: 52-61.
  • Wardle NJ, Kalber T, Bell JD, Bligh SWA (2011) Synthesis and characterisation of a novel tubulin-directed DO3A–colchicine conjugate with potential theranostic features, Bioorg. Med. Chem. Letters, 21:3346-3348.
  • Yu D-G, Branford-White C, Bligh SWA, White K, Chatterton NP, Zhu LM (2011) Improving Polymer Nanofiber Quality Using a Modified Co-axial Electrospinning Process. Macromol. Rapid Commun., 32: 744-750.
  • Yu D-G, Zhu L-M, Bligh SWA, Branford-White C, White KN (2011) Coaxial electrospinning with organic solvent for controlling the size of self-assembled nanoparticlesw, Chem. Commun. 47:1216–1218.
  • Xu Y, Zhang Z, Geng F, Su S, White KN, Bligh SWA, Branford-White C, Wang ZT (2010) Treatment with qing'e, a kidney-invigorating chinese herbal formula, antagonizes the estrogen decline in ovariectomized mice. Rejuvenation Research, 13, 479-488.
  • Zhu J-J, Zhang C-F, Zhang M, Bligh SWA, Yang L, Wang Z-M, Wang ZT (2010) Separation and identification of three epimeric pairs of new C-glucosyl anthrones from Rumex dentatus by on-line high performance liquid chromatography-circular dichroism analysis. J. Chromatography A 1217:5384-5388.
  • Cheng XM, Zhao T, Yang T, Wang CH, Bligh SWA, Wang ZT (2010) HPLC Fingerprints combining with principal component analysis, hierarchical cluster analysis, and linear discriminant analysis for the classification and differentiation of Genus Peganum indigenious to China, Phytochem. Anal., 21:279-289.
  • Chen JZ , Chou GX,  Wang CH, Yang L, Bligh SWA, Wang ZT (2010) Characterization of new metabolites from in vivo biotransformation of norisoboldine by liquid chromatography-mass spectrometry and NMR spectroscopy, J Pharm Biomed Anal, 52:687-693.
  • Wardle NJ, Hudson HR, Bligh SWA (2010) O-Phosphotyrosine analogues; synthesis and therapeutic role in modulation of signal transduction, Current Organic Chemistry, 14:426-446.
  • Xiong A, Yang L, He Y, Zhang F, Wang J, Han H, Wang CH, Bligh SWA, Wang ZT (2009). Identification of metabolites of adonifoline, a hepatotoxic pyrrolizidine alkaloid, by liquid chromatography/tandem and high-resolution mass spectrometry. Rapid Commun Mass Spectrometry, 23:3907-3916.
  • Wang Y, Kong L, Lei XY, Hu LH, Zou, HF, Welbeck E, Bligh SWA, Wang ZT (2009) Comprehensive two-dimensional high-performance liquid chromatography system with immobilized liposome chromatography column and reversed-phase column for separation of complex traditional Chinese medicine Longdan Xiegan Decoction. J. Chromatography A 1216:2185-2191.
  • Wardle NJ, Hudson HR, Matthews RW, Nunn C, Vella C and Bligh SWA (2009) Presentation of the β-Carboxamidophosphonate Arrangement in Substrate Structures Targeting HIV-1 PR. Letters in Drug Design & Discovery 6:139-145.
  • Yu D-G, Shen X-X, Branford-White C, White K, Zhu L-M and Bligh SWA (2009) Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers. Nanotechnology 20:055104.
  • Wardle NJ, Bligh SWA and Hudson HR (2008) Organophosphorus Compounds: Intervention in Mechanisms of Signal Transduction Relevant to Proliferative, Immunological and Circulatory Disorders Curr. Med. Chem. 15: 2230-2257.
  • Wang SC, Bligh SWA, Zhu CL, Shi SS, Wang ZT, Hu ZB, Crowder J, Branford-White C, Vella C (2008) Sulfated beta-Glucan Derived from Oat Bran with Potent Anti-HIV Activity, J. Agric. Food Chem. 56:2624-2629.
  • Wang Y, Yang L, He Y-Q, Wang C-H, Welbeck EW, Bligh SWA, Wang ZT (2008) Characterization of fifty-one flavonoids in a Chinese herbal prescription Longdan Xiegan Decoction by high-performance liquid chromatography coupled to electrospray ionization tandem mass spectrometry and photodiode array detection, Rapid Commun Mass Spectormetry, 22:1767-1778.
  • Liu JQ, Zhang M, Zhang CF, Qi HY; Bashall A, Bligh SWA, Wang ZT (2008) Cytotoxic sesquiterpenes from Ligularia platyglossa, Phytochemistry, 69:2231-2236
  • Zhang F, Wang CH, Wang W, Chen LX, Ma HY, Zhang CF, Zhang M, Bligh SWA, Wang ZT (2008) Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens, Phytochem. Anal. 19:25-31.
  • Wang Y, Kong L, Hu LH, Lei XY, Yang L, Chou GX, Zou HF, Wang CH, Bligh SWA and Wang ZT (2007) Biological fingerprinting analysis of the traditional Chinese prescription Longdan Xiegan Decoction by on/off-line comprehensive two-dimensional biochromatography, J Chromatography B, 860:185-194.
  • Wang SC, Bligh SWA, Zhu CL, Shi SS, Wang ZT, Hu ZB, Crowder J, Branford-White C, Vella C (2008) Sulfated beta-Glucan Derived from Oat Bran with Potent Anti-HIV Activity, J. Agric. Food Chem. 56:2624-2629.
  • Zhang F, Wang CH, Xiong AZ, Wang W, Yang L, Branford-White CJ, Wang ZT, Bligh SWA (2007) Quantitative Analysis of Total Retronecine Esters-type Pyrrolizidine Alkaloids in Plant by High Performance Liquid Chromatography, Anal. Chim. Acta, 605:94-101.
  • Wardle NJ, Bligh SWA and Hudson HR (2007) Omega-Phosphinyl-alpha-amino acids: synthesis and development towards use as therapeutic agents, Current Organic Chemistry, 11: (18) 1635-1651.
  • Wang CH, Cheng XM, He YQ, Bligh SWA, White KN, Branford-White CJ, Wang ZT (2007) Pharmacokinetic Behavior of Gentiopicroside From Decoction of Radix Gentianae, Gentiana Macrophylla After Oral Administration in Rats: a Pharmacokinetic Comaprison with Gentiopicroside after Oral and Intravenous Administration Alone, Arch. Pharm. Res. 30:1149-1154.
  • Wang CH, Cheng XM, Bligh SWA, White KN, Branford-White CJ, Wang ZT (2007) Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats - comparison with gentiopicroside alone, J. Pharma. Biomed. Anal. 44:1113-1117.
  • Wang SC, Bligh SWA, Shi SS, Wang ZT, Hu ZB, Crowder J, Branford-White C and Vella C (2007) Structural features and anti-HIV-1 activity of novel polysaccharides from red algae Grateloupia longifolia and Grateloupia finicina, Int. J. Biol. Macromol 41:369-375.
  • Wardle NJ, Herlihy A, So PW, Bell JD and Bligh SWA (2007) Synthesis of a novel ‘smart’ bifunctional chelating agent 1-(2-[ß,D-galactopyranosyloxy]ethyl)-7-(1-carboxy-3-[4-aminophenyl]propyl)-4,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (Gal-PA-DO3A-NH2) and its Gd(III) complex. Bioorganic and Med. Chem. 15:4714-4721.
  • Yang L, Nakamura N, Hattori M, Wang Z-T, Bligh SWA and Xu L-S (2007) HPLC-DAD-ESIMSn for simultaneous analysis of cis-, trans- and dihydro- 2-glucosyloxycinnamic acid derivatives from Dendrobium medicinal plants. Rapid Commun. Mass Spectrom. 21:1833-1840.
  • Gudasi KB, Patil SA, Vadavi RS, Shenoyl RV, Nethaji M and Bligh SWA (2006) Synthesis and spectral investigation of manganese(II), cadmium(II) and oxovanadium(IV) complexes with 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone): crystal structure of manganese(II) and cadmium(II) complexes, Inorg. Chim. Acta, 359: 3229-3236.
  • Yang L, Qin L-H, Bligh SWA, Bashall A, Zhang C-F, Zhang M, Wang Z-T and Xu L-S (2006) A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities, Bioorg & Med Chem, 14: 3496-3501.
  • Simon GA, McFarlane-Anderson N, Fletcher H, Golden K, Wharfe G, Ogegbo O, Bligh SWA, Branford-White CJ. (2006) Phytoestrogen levels in Selected Jamaican Food C, WIMJ, (Supp 4) 55:24.
  • Wu T, Cheng X-M, Bligh SWA, Chou G-X, Branford-White CJ, Bashall A and Wang Z-T (2005) Multiflorane triterpene esters from the seeds of Trichosanthes kirilowii, Helv. Chim. Acta, 88: 2617-2623.
  • Wardle NJ, Bligh SWA and Hudson HR (2005) Organophosphorus chemistry: Therapeutic intervention in mechanisms of viral and cellular replication, Current Organic Chemistry, 9: 1803-1828.
  • Zhang G-N, Zhong LY, Bligh SWA, Guo Y-L, Zhang C-F, Wang Z-T and Xu L-S (2005) Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum, Phytochemistry, 66:1113-1120.
  • Wu T, Bligh SWA, Gu L-H, Liu H-P, Cheng X-M, BranfordWhite CJ, Wang Z-T(2005) Simultaneous determination of six isoflavonoids in commercial Radix Astragli by HPLC-UV , Fitoterpia, 76:157-165.
  • Collinson A, Bligh SWA, Graham D, Mott H, Chalk PA, Korniotis N and Lowe PN (2004) Fluorescence properties of GFP FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, PAK, Assay and Drug Discovery Technology, 2:659-673.
  • Cheng Z-H, Wu T, Bashall A, Bligh SWA and Yu B-Y (2004) cis-Eudesmane Sesquiterpene Glycosides from Liriope muscari and Ophiopogon japonicus J. Natural Products, 67:1761-1763.
  • Wang C-H, White KN, Bligh SWA, BranfordWhite CJ, Wang Z-T (2004) Pharmacokinetics and Tissue Distribution of Gentiopicroside Following Oral and Intravenous Administration in Mice Eur. J. Drug Metabolism and Pharmacokinetics, 29:199-203.
  • Naik DG, Mujumdar AM, Waghole RJ, Misar AV, Bligh SWA, Bashall A & Crowder J (2004) Structural Characterisation and Anti-inflammatory Activity of Taraxer-14-en-3b-ol from Sterculia foetida Leaves. Planta Medica, 70, 68-69.
  • Bligh SWA, Haley T and Lowe P (2003) Measurement of dissociation constants of inhibitors binding to Src SH2 domain protein by non-covalent electrospray ionisation mass spectrometry. J. Mol. Recognit., 16, 139-147.
  • Bligh SWA, Bashall A, Garrud C, McPartlin M, Wardle N, White KN, Padhye S, Barve V and Kundu G (2003) Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)-chloroplatinum(II) with nucleosides and its biological activity. J. Chem. Soc., Dalton Trans. 184 - 188.
  • Bligh SWA, Choi N, Evagorou EG, McPartlin M and White KN (2001) Dimeric yttrium(III) and neodymium(III) macrocyclic complexes - Potential catalysts for hydrolysis of double-stranded DNA. J. Chem. Soc. Dalton Trans., 3169-3172.
  • Bligh SWA, Choi N, McGrath CM, and McPartlin M (2000) Synthesis and structural properties of metal complexes of dialkyl a-hydroxyiminophosphonates. J. Chem. Soc. Dalton Trans, 2587-2594.
  • Bligh SWA, Chowdhury AHMS, Geraldes CFC, de Lima JJP and Prata MIM (2000) Characterisation of 111In3+ complexes of DTPA-amide derivatives: biodistribution and clearance studied by gamma imaging. Nucl Med and Biology, 27, 605-610.

Grants and Funding

  • Visiting Fellowship at GlaxoSmithKline (2003, 3 months)
  • MRC/EPSRC Discipline Hopper Award (2002, 12 months)
  • The Royal Society, Industry Fellowship (2001, 6 months)
  • EU LSF PARABIO Biomedical NMR Travel & Visiting Grants (2001)
  • The Royal Society of Chemistry, Journal Grant, visit to India (2001)
  • The Royal Society, Industry Fellowship (2000, 12 months)


Consultancy

NMR and X-ray consultancy service at London Metropolitan University






 

   Company Information    Page last updated 20 January 2012     Contact Page Owner (Annie Bligh)