Professor Jameel Inal

Jameel Inal is the Professor of Immunology and Director of the Cellular and Molecular Immunology Research Centre.


Professor Jameel Inal  

Jameel Inal is a Professor of Immunology and the Director of the Cellular and Molecular Immunology Research Centre. He holds a PhD, BSc(hons), FSB,  and CBiol.

Subject specialism

  • Immunology
  • Complement system
  • Plasma membrane-derived microvesicles

Professional activity

  • Editorial Advisory panel member of Biochemical Journal
  • Editorial Advisory Panel of The Open Parasitol. J. (2008)
  • Ad Hoc Reviewer for: J. Immunol.; Clin. Exp. Immunol.; Scand. J. Immunol.; Parasitology; Exp. Parasitol; Prot. Expr. Purif.; Virus Research; FEMS Immunol. & Med. Microbiol.
  • Independent Chair, PhD viva voce
  • Fellow of the Institute of Biology
  • Fellow of the Royal Society of Medicine
  • London Met coordinator for UK National Stem Cell Network Steering Committee
  • Member of the International Complement Society
  • Member of the European Complement Network
  • Member of the American Association for Immunologists
  • Member of the Federation of American Societies for Experimental Biology
  • Member of the Biochemical Society
  • Member of the National Conference of University Professors (NCUP)

Research interests

  • Plasma membrane-derived vesicles.
  • Complement regulation by host and parasite.
  • Synthetic peptide design for complement inhibition.

Collaborators:

  • Dr M Ramirez, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil
  • Dr RB Sim, Dept of Biochemistry, Oxford University

Research awards/prizes:

  • Royal Society
  • Roche Research Foundation
  • Novartis Research Foundation
  • Wood-Whelan Research Fellowship (IUBMB)
  • NHS University Hospital Basel - Research Prize (December, 2002)
  • ‘Recognition of excellent contribution to complement in human disease’ for PhD student, Hui, K.M. (International Complement Society, 2005)
  • Antwi-Baffour, S, Kholia, S, Aryee, YK-D, Ansa-Addo, EA, Stratton, D, Lange, S and Inal, JM (2010) Human Plasma Membrane-derived Vesicles inhibit the phagocytosis of apoptotic cells - possible role in SLE. Biochem Biophys. Res. Commun. in press DOI: 10.1016/j.bbrc.2010.06.079
  • Evans-Osses, I, Ansa-Addo, E, Inal, JM and Ramirez, MI (2010) Involvement of lectin pathway activation in the complement killing of Giardia intestinalis. Biochem. Biophys. Res. Commun. 395, 382
  • dos Santos Cestari, I, Krarup, A, Sim, RB, Inal, JM* and Ramirez, MI* (2009) Crucial role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi. Mol. Immunol. 47, 426
  • dos Santos Cestari, I, Evans-Osses, I, Freitas, JC, Inal, JM* and Ramirez, MI* (2008) Complement C2 Receptor Inhibitor Trispanning confers an increased ability to resist complement-mediated lysis in Trypanosoma cruzi. J. Inf. Dis. 198: 1276
  • Moll, S, Lange, S, Mihatsch, MJ, Dragic, Z, Schifferli, JA* and Inal, JM (2006) Complement C2 receptor inhibitor trispanning (CRIT) is expressed on podocytes in normal human kidney and upregulated in membranous glomerulonephritis. Kidney Int. 69, 1961
  • Inal, JM,* Hui, K-M, Miot, S, Lange, S, Ramirez, MI, Schneider, B, Krueger, G, and Schifferli, JA (2005) Complement C2 Receptor Inhibitor Trispanning: A novel human complement inhibitory receptor. J. Immunol., 174, 356
  • Horakova, E, Gasser, O, Sadallah, S, Inal, JM, Bourgeois, G, Ziekau, I, Klimkait, T, Schifferli, JA* (2003) Complement mediates the binding of HIV immune complexes and HIV alone to erythrocytes. J. Immunol. 173, 4236.
  • Inal, JM,* Schneider, B, Armanini, M, and Schifferli, JA (2003) A peptide derived from the parasite receptor, Complement C2 Receptor Inhibitor Trispanning, CRIT, suppresses immune complex-mediated inflammation in mice. J. Immunol 170, 4310.
  • Inal, JM* and Schifferli, JA (2002) Complement C2 receptor inhibitor trispanning (CRIT) and the Beta-chain of C4 share a binding site for complement C2. J. Immunol. 168, 5213.

    *corresponding/senior author

Email: j.inal@londonmet.ac.uk

Telephone: +44 (0)20 7133 2122

Room: T12-03, Tower Building