Dr Kevin Devine
Dr Kevin Devine has subject specialisms in the following areas:
- bio-organic, organic and medicinal chemistry
- analytical procedures in toxicology and forensic science
Kevin's research interests include:
- The design and synthesis of novel protozoan glutamate dehydrogenase inhibitors, and their potential as new anti-malarial drugs.
- The design of novel proteins and nucleic acids which contain non-standard components (amino acids, nucleobases and sugars); to address the big question: Must life, as we know it, contain biological macromolecules that contain the same set of building blocks (amino acids and nucleosides) found here on planet Earth?
Kevin is a also a member of London Met's research centre, the Molecular Systems for Health Research Group. This is a multi-disciplinary group with expertise in chemistry, phytochemistry, pharmacology, molecular biology and genetics, and is focused on strategic areas of analytical, diagnostic and therapeutic applications in biomedical science.
- Probing minor groove recognition contacts by DNA polymerases and reverse transcriptases using 3-deaza-2’-deoxyadenosine. Steven A Benner, Kevin G Devine and Cynthia Whitehead. Nucl. Acids Res., (2004), 32(7), 2241-2250.
- Synthesis and characterization of Oligonucleotides containing 2'-deoxyxanthosine using phosphoramidite chemistry. Simona C Jurczyk, Jennifer Horlacher, Kevin G Devine, Steven A Benner and Thomas R Battersby. Helvetica Chimica Acta, (2000), 83, 1517-1524.
- The missing organic molecules on Mars. SA Benner, KG Devine, L Matveeva and DH Powell. PNAS, (2000), 97, 2425-2430.
- Aryl phosphate derivatives of AZT retain activity against HIV-1 in cell lines which are resistant to the action of AZT. KG Devine, AJ Hay, C McGuigan, N Mahmood and RN Pathirana. Antiviral Research, (1992), 17, 311-21.
- Novel phosphate derivatives of zidovudine as anti-HIV compounds. KG Devine, C McGuigan, DJ Jeffries, TJ O'Connor and D. Kinchington. AIDS, (1990), 4(4), 371-2.
- Highly Reactive Condensing Agents for the synthesis of Oligonucleotides by the phosphotriester approach. KG Devine and CB Reese. Tetrahedron Letts, (1986), 27(45), 5529-32.