Dr Gary McLean

Dr Gary McLean is a reader in molecular immunology.


Dr Gary McLean  

Dr Gary McLean is a reader in molecular immunology and holds a PhD, BSc, and DipSci.

Subject specialisms

  • Infectious diseases
  • Immunology
  • Antibody engineering

Professional activity

Research interests

  • Rhinovirus vaccines
  • Neutralising antibody structure and function
  • Primary B cell immunodeficiency

JW Schrader and GR McLean. Multispecificity of a recombinant anti-ras monoclonal antibody. J Mol Recognit. 2017;e2683.
A Manghera and GR McLean. HCMV vaccination: progress and perspectives of recombinant gB. Future Virology 11(6):439-449, 2016
GR Williams, I Kubajewska, NS Glanville, SL Johnston and GR McLean. The potential for a protective vaccine for rhinovirus infections. Expert Review of Vaccines 15(5), 569-571, 2016
GR McLean
. Developing a vaccine for human rhinoviruses. Journal of Vaccines and Immunization 2(3):16-20, 2014
R Privolizzi, R Solari, SL Johnston, GR McLean. The application of prophylactic antibodies for rhinovirus infections.  Antiviral Chemistry and Chemotherapy 23:173-177, 2014
N Glanville*, GR McLean*, B Guy, V Lecouturier, C Berry, Y Girerd, C Gregoire, RP Walton, RM Pearson, T Kebadze,  N Burdin, NW Bartlett, JW Almond and SL Johnston. Cross-serotype immunity induced by immunization with a conserved rhinovirus capsid proteinPLoS Pathogens 9(9): e1003669, 2013

*co-first authors

S Traub, A Nikonova, A Carruthers, R Dunmore, K Vousden, L Gogsadze, W Hao, Q Zhu, J Zhu, M Dymond, GR McLean, RP Walton, N Glanville, A Humbles, M Khaitov, T Wells, R Kolbeck, AJ Leishman, MA Sleeman, NW Bartlett, SL Johnston. An anti-human ICAM-1 antibody inhibits rhinoviral exacerbation of lung inflammation. PLoS Pathogens 9(8): e1003520, 2013
JR Mader, ZT Resch, GR McLean, JH Mikkelsen, C Oxvig, RJ Marler, CA Conover. Mice Deficient in Pregnancy-Associated Plasma Protein-A Show Resistance to the Development of Diabetic Nephropathy. Journal of Endocrinology 219:51-58, 2013
RS Thompson, NM Khaskhely, DJ Legget, J Mosakowski, S Khuder, GR McLean, MAJ Westerink. Isolation and characterization of human polyreactive pneumococcal polysaccharide antibodies. Open Journal of Immunology 2(3):98-110, 2012
G Sapparapu, S Planque, Y Mitsuda, GR McLean, Y Nishiyama, S Paul. Constant domain-regulated antibody catalysis. Journal of Biological Chemistry 287:36096-36104, 2012
GR McLean, RP Walton, S Shetty, N Paktiawal, T Kebadze, L Gogsadze, K Niespodziana, R Valenta, NW Bartlett, SL Johnston Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1. Antiviral Research 95(3):193-201, 2012
NW Bartlett, GR McLean, Y-S Chang and SL Johnston. Genetics and epidemiology: asthma and infection. Curr Opin Allergy Clin Immunol 9:395-400, 2009
CA Thomson, S Bryson, GR McLean, AL Creagh, EF Pai, JW Schrader. Germline V-genes sculpt the binding site of a family of antibodies neutralizing human cytomegalovirus. EMBO J27(19):2592-2602,2008
M Noseda and GR McLean. Where did the scientific method go? Nature Biotechnology 26(1):28-29, 2008
JW Schrader and GR McLean. Location, location, timing: an analysis of cytomegalovirus epitopes for neutralizing antibodies. Immunology Letters 112:58-60, 2007
GR McLean, C Cho, B Trotter, JW Schrader. RIVETS: The recombinant immunoglobulin and viral epitope tag system. Journal of Immunological Methods 315:208-213, 2006
GR McLean, C Cho, JW Schrader. Autoreactivity of primary human immunoglobulins ancestral to hypermutated human antibodies that neutralize HCMV. Molecular Immunology 43:2012-2022, 2006
GR McLean, M Torres, B Trotter, M Noseda, S Bryson, EF Pai, JW Schrader, A Casadevall.A point mutation in the CH3 domain of human IgG3 inhibits antibody secretion without affecting antigen specificity. Molecular Immunology 42(9):1111-1119, 2005
GR McLean, O Olsen, IN Watt, K Leslie, JS Babcook, JW Schrader.  Recognition of HCMV by primary immunoglobulins identifies an innate foundation to an adaptive immune response. Journal of Immunology 174:4768-4778, 2005
GR McLean, K Miller, JW Schrader, A Junker.  Biased IgG Isotype Production in a Case of HIGM4 Syndrome. Clinical and Diagnostic Laboratory Immunology 11(6):1192-1193, 2004
AH Lucas, GR McLean, DC Reason, The Pediatric Collaborative Group, AP O'Connor, MC Felton, KD Moulton.  Molecular ontogeny of the human antibody repertoire to the Haemophilus influenzae type b polysaccharide: Expression of canonical variable regions and their variants in vaccinated infants. Clinical Immunology 108(2):119-127, 2003
J Navoa, S Laal, L-A Pirofski, GR McLean, Z Dai, JB Robbins, R Schneerson, A Casadevall, A Glatman-Freedman. Specificity and diversity of antibodies to Mycobacterium tuberculosis arabinomannan. Clinical and Diagnostic Laboratory Immunology 10(1):88-94, 2003
GR McLean, M Torres, N Elguezabal, A Nakouzi, A Casadevall. Isotype can affect the fine specificity of an antibody for a polysaccharide antigen. Journal of Immunology 169:1379-1386, 2002
GR McLean, A Nakouzi, A Casadevall, NS Green. Human and murine immunoglobulin expression vector cassettes. Molecular Immunology 37(14):837-845, 2000
GR McLean, MJ Williams, CS Woodhouse, HJ Ziltener. Transcobalamin II and in vitro proliferation of leukemic cells. Leukemia and Lymphoma 30:101-109, 1998
GR McLean, PM Pathare, DS Wilbur, AC Morgan, CS Woodhouse, JW Schrader, HJ Ziltener. Analogs of cobalamin inhibit the growth of leukemia cells in vitro. Cancer Research 57:4015-4022, 1997
GR McLean, EV Quadros, SP Rothenberg, AC Morgan, JW Schrader, HJ Ziltener. Antibodies to transcobalamin II block in vitro proliferation of leukemic cells. Blood 89:235-242, 1997
G McLean and F Hilbink. Use of dried blood on filter paper in the ELISA for Brucella abortus. Journal of Immunological Methods 123:39-43, 1989

 

Email: g.mclean@londonmet.ac.uk

Telephone: +44 (0)20 7133 4070

Room: T9-07c, Tower Building