Anastasia Kalea RD, PhD, AFHEA
Dr Anastasia Kalea is a lecturer in Dietetics and Nutrition. She holds a PhD in Food & Nutrition Sciences (University of Maine, Orono, ME, USA) and a BSc (Hons) in Human Nutrition and Dietetics (Harokopio University, Athens, Greece).
Dr Anastasia Kalea graduated with a BSc (Hons) in Human Nutrition and Dietetics from Harokopio University (Greece) after fulfilling her internship on clinical nutrition in Athens. She worked as a dietitian and then followed her interest in biomedical research in the USA, where she completed her doctorate studies on the dietary effect of nutrients on vascular physiology and structure at the University of Maine (ME, USA).
During her postdoctoral training she studied the effect of bioactive compounds on vasomotor tone and in the prevention of genetic hypertension and studied the dietary patterns of obese and overweight Mediterranean adolescents. Dr Kalea was awarded a Juvenile Diabetes Research Foundation (JDRF) fellowship to study diabetes complications and the role of the receptor of advanced glycation end-products (RAGE) at the Dept of Surgery at Columbia University in New York (NY, USA), and later at the Dept of Nephrology/ Hypertension at Northwestern University in Chicago (IL, USA). In 2011 Dr Kalea moved to London and joined the UCL Centre for Cardiovascular Genetics team to research the genetic and epigenetic mechanisms regulating metabolic processes and contributing to cardiovascular diseases. She has received funding from the BHF and the NIHR BRC and has active collaborations within the UK and oversees on projects focusing on novel diagnostic tools and therapeutic targets for cardiovascular diseases.
Dr Kalea is an Associate Fellow of the Higher Education Academy, is registered with the Health and Care Professions Council (HCPC) as a Dietitian (Registration #DT28154), and is a member of the British Dietetic Association.
- Molecular Nutrition
- Cardiovascular; Nutrigenetics
- Mechanisms of disease
- Fundamentals of Human Nutrition
- Dr Kalea serves as a reviewer for several peer-reviewed scientific journals and has been invited to contribute as a scientific committee member, fund-raising committee member or abstract reviewer in national and international scientific conferences in Nutrition and Dietetics.
- Dr Kalea has supervised a number of Undergraduate and Graduate students (MSc and PhD), has offered talks on academic career paths and has attended extensive training on leadership and professional development of early career scientists.
- Guidelines for the functional annotation of microRNAs using the Gene Ontology Huntley RP, Sitnikov D, Orlic-Milacic M, Balakrishnan R, D'Eustachio P, Gillespie ME, Howe D, Kalea AZ, Maegdefessel L, Osumi-Sutherland D, Petri V, Smith JR, Van Auken K, Wood V, Zampetaki A, Mayr M, Lovering RC. RNA. 2016 Feb 25. [Epub ahead of print] PMID: 26917558
- Demonstration of the presence of the "deleted" MIR122 gene in HepG2 cells. Hamad IA, Fei Y, Kalea AZ, Yin D, Smith AJ, Palmen J, Humphries SE, Talmud PJ, Walker AP. PLoS One. 2015 Mar 26;10(3):e0122471. doi: 10.1371/journal.pone.0122471. eCollection 2015. PMID: 25811611
- Upregulation of gingival tissue miR-200b in obese periodontitis subjects. Kalea AZ, Hoteit R, Suvan J, Lovering RC, Palmen J, Cooper JA, Khodiyar VK, Harrington Z, Humphries SE, D'Aiuto F. J Dent Res. 2015 Mar;94(3 Suppl):59S-69S. doi: 10.1177/0022034514568197. Epub 2015 Jan 28 PMID: 25630869
- Attenuation of alpha-adrenergic-induced vasoconstriction by dietary wild blueberries (Vaccinium angustifolium) is mediated by the NO-cGMP pathway in spontaneously hypertensive rats (SHRs). Kristo AS, Kalea AZ, Schuschke DA, Klimis-Zacas D. Int J Food Sci Nutr. 2013 Dec;64(8):979-87. doi: 10.3109/09637486.2013.825698. Epub 2013 Aug 15. PMID: 23944991
- Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels. Exeter HJ, Folkersen L, Palmen J, Franco-Cereceda A, Cooper JA, Kalea AZ, Hooft FV, Eriksson P, Humphries SE, Talmud PJ. PLoS One. 2012;7(7):e41139. doi: 10.1371/journal.pone.0041139. Epub 2012 Jul 17 PMID: 22879865
- Genomic research to identify novel pathways in the development of abdominal aortic aneurysm. Harrison SC, Kalea AZ, Holmes MV, Agu O, Humphries SE. Cardiol Res Pract. 2012;2012:852829. doi: 10.1155/2012/852829. Epub 2012 Jan 29. PMID:
- Genetic susceptibility for coronary heart disease and type 2 diabetes complications. Kalea AZ, Harrison SC, Stephens JW, Talmud PJ. Clin Chem. 2012 May;58(5):818-20. doi: 10.1373/clinchem.2012.182725. Epub 2012 Feb 23. No abstract available PMID: 22361938.
- Alternative splicing of RAGE: roles in biology and disease. Kalea AZ, Schmidt AM, Hudson BI. Front Biosci (Landmark Ed). 2011 Jun 1;16:2756-70. Review PMID: 21622207
- Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS). Hudson BI, Moon YP, Kalea AZ, Khatri M, Marquez C, Schmidt AM, Paik MC, Yoshita M, Sacco RL, DeCarli C, Wright CB, Elkind MS. Atherosclerosis. 2011 May;216(1):192-8. doi: 10.1016/j.atherosclerosis.2011.01.024. Epub 2011 Jan 21 PMID: 21316677
- Food consumption patterns in Mediterranean adolescents: are there differences between overweight and normal-weight adolescents? Yannakoulia M, Brussee SE, Drichoutis AC, Kalea AZ, Yiannakouris N, Matalas AL, Klimis-Zacas D. J Nutr Educ Behav. 2012 May-Jun;44(3):233-9. doi: 10.1016/j.jneb.2010.02.005. Epub 2011 Feb 5. PMID: 21296024
- A wild blueberry-enriched diet (Vaccinium angustifolium) improves vascular tone in the adult spontaneously hypertensive rat. Kristo AS, Kalea AZ, Schuschke DA, Klimis-Zacas DJ. J Agric Food Chem. 2010 Nov 24;58(22):11600-5. doi: 10.1021/jf101839u. Epub 2010 Oct 22. PMID: 20964405
- The temporal effect of a wild blueberry (Vaccinium angustifolium)-enriched diet on vasomotor tone in the Sprague-Dawley rat. Del Bo' C, Kristo AS, Kalea AZ, Ciappellano S, Riso P, Porrini M, Klimis-Zacas D. Nutr Metab Cardiovasc Dis. 2012 Feb;22(2):127-32. doi: 10.1016/j.numecd.2010.05.004. Epub 2010 Aug 14 PMID: 20709513
- Alternatively spliced RAGEv1 inhibits tumorigenesis through suppression of JNK signaling. Kalea AZ, See F, Harja E, Arriero M, Schmidt AM, Hudson BI. Cancer Res. 2010 Jul 1;70(13):5628-38. doi: 10.1158/0008-5472.CAN-10-0595. Epub 2010 Jun 22 PMID: 20570900
- Inflammatory stress in primary venous and aortic endothelial cells of type 1 diabetic mice. Bucciarelli LG, Pollreisz A, Kebschull M, Ganda A, Kalea AZ, Hudson BI, Zou YS, Lalla E, Ramasamy R, Colombo PC, Schmidt AM, Yan SF. Diab Vasc Dis Res. 2009 Oct;6(4):249-61. doi: 10.1177/1479164109338775 PMID: 20368219
- Apelin and ACE2 in cardiovascular disease. Kalea AZ, Batlle D. Curr Opin Investig Drugs. 2010 Mar;11(3):273-82. Review PMID: 20178040
- Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. Kalea AZ, Clark K, Schuschke DA, Klimis-Zacas DJ. J Med Food. 2009 Feb;12(1):21-8. doi: 10.1089/jmf.2008.0078 PMID: 19298192
- RAGE: a novel biological and genetic marker for vascular disease. Kalea AZ, Schmidt AM, Hudson BI. Clin Sci (Lond). 2009 Apr;116(8):621-37. doi: 10.1042/CS20080494. Review PMID: 19275767
- Alternative splicing of the murine receptor for advanced glycation end-products (RAGE) gene. Kalea AZ, Reiniger N, Yang H, Arriero M, Schmidt AM, Hudson BI. FASEB J. 2009 Jun;23(6):1766-74. doi: 10.1096/fj.08-117739. Epub 2009 Jan 22 PMID: 19164451
- Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats. Kalea AZ, Clark K, Schuschke DA, Kristo AS, Klimis-Zacas DJ. J Nutr Biochem. 2010 Jan;21(1):14-22. doi: 10.1016/j.jnutbio.2008.09.005. Epub 2009 Jan 20. PMID: 19157824
- Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42. Hudson BI, Kalea AZ, Del Mar Arriero M, Harja E, Boulanger E, D'Agati V, Schmidt AM. J Biol Chem. 2008 Dec 5;283(49):34457-68. doi: 10.1074/jbc.M801465200. Epub 2008 Oct 15 PMID: 18922799